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Indication & Dosage |
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| Oral |
| MILD TO MODERATE HTN NOT RESPONDING TO MONOTHERAPY |
| Adult:
(Amlodipine 5mg + lisinopril 5mg) Usual initial dose 1 tab O.D. May be increased to 2 tabs, if reqd. |
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| Precautions |
Renal impairment, hepatic impairment and CCF. Risk of hyperkalaemia increased in the presence of renal insufficiency, concurrent K supplements/potassium-sparing drugs. |
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Potentially Life-threatening
Adverse Drug Reactions |
Nausea, headache, dizziness, cough, diarrhoea, fatigue, rash, oedema, flushing, palpitation, chest pain, asthenia, dry mouth; elevations in BUN, serum creatinine and K may occur. |
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| Adverse Drug Reactions |
Angioneurotic oedema reported with ACE inhibitors. |
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| Interactions |
Patients on diuretics may experience exaggerated fall in BP; hyperkalaemia with concomitant use of potassium-sparing diuretics/potassium supplements may occur. Lisinopril may increase serum lithium levels. Indometacin may attenuate antihypertensive effect of lisinopril. Lisinopril reduces K loss caused by thiazides. |
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